Tadalafil, dapoxetine alone or in combination for the treatment of erectile dysfunction combined with premature ejaculation
Zhou, H1; Tang, S1
1: First Affiliated Hospital of Fujian Medical University, China
Objective: To evaluate the efficacy of tadalafil 5 mg daily, dapoxetine 30 mg on-demand or in combination for the treatment of erectile dysfunction (ED) combined with premature ejaculation (PE).
Methods: Sixty patients diagnosed as ED combined with PE were randomly divided into three groups: tadalafil 5 mg daily group, 30mg dapoxetine on demand group and combination groups, 20 cases were in each group respectively. The course of treatment was 2 months. The therapeutic effect of ED or PE was evaluated by the international index of erectile function -5 (IIEF-5) score or the premature ejaculation diagnostic questionnaire (PEDT) score before and after treatment, respectively.
Results: 16 cases’ erectile function was improved in 5mg tadalafil daily group, with an effective rate of 80%. In dapoxetine 30 mg on-demand group, only 6 cases of erectile function improved with an effective rate of 30%. In combination group, 18 cases of erectile function improved, the efficiency was 90%. There was significant difference among groups (P < 0.05). 9 cases of tadalafil 5mg daily group improved PE, the effective rate was 45%. 13 cases of dapoxetine 30 mg on-demand group had the improvement of PE, the efficiency was 65%. In combined group, 15 cases of PE improved, effective rate was 75%. The difference among groups was significant (P <0.05). In the 3 groups, the effective rate of PE in patients with ED improvement was significantly higher than that in patients without ED improvement.
Conclusion: For PE with ED, improving erectile function in patients may improve PE.
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