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Long term follow up of patients operated for penile cancer : A retrospective survival bicentric study

Tremblais, B1; Morel Journel, N2; Ruffion, A2; Galonnier, F 2; Terrier, JE2

1: CHLS , Lyon,France; 2: CHLS, Lyon, France

Introduction: In Western countries, penile cancer is a rare disease whose incidence is estimated to be 1 per 100 000 men. Its morbidity and mortality are very high and nowadays conservative surgery has become the reference. The aim of this study was to analyse the overall and recurrence free survival according to the stage, the grade of the tumor and the type of surgery performed.

Methods: A retrospective bicentric cohort study of 96 patients treated for penile cancer between February 2006 and March 2016. Epidemiological and clinical data were collected on electronic files for each patient. The survival analysis was performed with the Kaplan-Meier model and log-rank test. The COX model was used for univariate and multivariate analysis.

 Results: The median age was 69 years with an average follow up of 32 months. 45 patients were included in the conservative group compared to 51 in the partial-total amputation group.No statistically significant difference was found between these two groups in terms of recurrence free survival with a global figure of 27 months. No distant metastases were found in the conservative group. At the end of the data collection, the death rate was 28% including more than two-thirds specifically related to the penile cancer. Conclusion: Our study highlights the severity of the penile cancer with 19% of specific mortality.

We also report that conservative surgery aimed to reduce postoperative morbidity , do not increase the free recurrence survival rate.


Work supported by industry: no.

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