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The status of serum urotensin-II in patients with erectile dysfunction

Singh, SK1; Durga Prasad, B1; Mavuduru, R1; Mandal, AK1; Prasad, R1

1: Post Graduate Institute of Medical Education & Research, India

Objective : To evaluate the status of Urotensin-II (U-II) in patients with erectile dysfunction (ED) and the effect of tadalafil on U-II.

Materials and Methods: Men between 40 to 70 years with ED and without any known risk factors for endothelial dysfunction were enrolled into this study. Fifty age matched healthy volunteers served as controls. ED in cases was assessed using International Index for Erectile Function score (IIEF-5). Endothelial dysfunction was assessed by flow mediated dilatation (FMD) of brachial artery and serum U-II levels by ELISA kits in both cases and controls. The cases of ED were treated with tadalafil 10 mg once daily orally and were re-evaluated at 4 weeks of therapy.

Results: Sixty one men with a mean age of 47.93 ± 8.84 years suffering from ED for at least 6 months were enrolled. FMD was significantly lower in cases (+9.42 ± 11.21 vs +13.29 ± 11.24%; p=0.04). Baseline U-II was not different significantly between cases and controls (3524.21 ± 365.26 vs 3511.42 ± 346.81 pg/ml; p=0.98) and this was true across various IIEF sub-groups of cases (p=0.32) except in those ED patients with Lower Urinary Tract Symptoms (LUTS) it was significantly higher (3688.17 ± 532.1 vs 3474.31 ± 286.91; p=0.026). Serum U-II had a insignificant positive correlation with IIEF score (r2 = +0.12; p=0.36). A total of 55 patients completed follow-up of four weeks of tadalafil therapy After tadalafil therapy, IIEF-5 improved significantly (9.21 ± 3.39 vs 18.5 ± 4.78; p=<0.0001) and FMD improved insignificantly, (+9.42 ± 11.21 vs +10.16 ± 8.56%; p=0.4) but there was no significant change in serum U-II after therapy (3538.67 ± 382.53 vs 3567.21 ± 431.5 pg/ml; p=0.41).

Conclusions: Serum Urotensin II is neither a marker of erectile dysfunction nor of endothelial dysfunction. It may have a role in ED associated with LUTS, which needs further study.


Work supported by industry: no.

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