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Semen quality assessment in 3425 fertile men in Guangdong province

Shu, FP1; Wen, YA1; Xing, RW 2; Zhou, BW1; Huang, B1; Mu, HQ3; Zou, YG4; Zhao, SC1; Mao, XM5

1: Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province,China; 2: Department of Urology, Weihai Hospital, Qingdao University, Weihai, Shandong Province, China; 3: Department of Urology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province,China; 4: Department of Stomatology, NanFang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China ; 5: Department of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong Province, China

Objective: This study was designed to evaluate the semen quality of men who proven fertility in Guangdong province over the last 4 years, according to the World Health Organization laboratory manual for the examination and processing of human semen (WHO, 2010) .

Methods: We make a retrospective analysis of semen samples of 3425 men with proven fertility as they had fathered at least 1 children between 2012 and 2016. Shapiro-Wilk test , Kruskal–Wallis analysis and logistic regression model were used for statistical analyses.

Results: For the periods 2012-2013, 2013-2014, 2014-2015, 2015-2016, the mean (standard deviation[SD]) sperm concentration, percentage of sperm normal morphology and sperm progressive motility were decreased from 85.1 (59.13) ´106 ml-1 to 61.3 (44.4) ´ 106 ml-1 (P<0.001), from 15.3% (8.88) to 13.4% (6.5) (P=0.001) and from 47.6% (13.7) to 44.8% (12.7) (P=0.004) , respectively. Meanwhile, decreasing trends with year of semen analysis at the cut-point analyzed in sperm concentration, number of normal forms and sperm progressive motility were found (P<0.001). 78.5% of cases had displayed normal semen parameters, but 21.5% of them showed below normal threshold values in at least one semen parameters.

Conclusions: A time-related decline in semen quality was found in Chinese fertile men in Guangdong province over the last 4 years. And a considerable part of Chinese fertile males showed below normal threshold values.

Disclosure:

Work supported by industry: no.

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