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Tribulus terrestris can change the morphology of the penis? A study developed in a model of pre-disposition to benign prostatic hyperplasia

Da Silva, MHA1; Gonçalves, GFB1; Correa, CL1Sampaio, FJ1; De Souza, DB1

1: Urogenital Research Unit, Brazil

Objective: The objective of this study is to investigate if the treatment with Tribulus terrestris causes histomorphometric changes in the penis of SHR rats.

Methods: We used 40 rats divided into 4 groups: Ctrl - group composed of untreated Wistar Kyoto rats; Ctrl+T - Kyoto Wistar rats treated with Tribulus terrestris (100mg/ Kg/day); BPH - untreated SHR; BPH+T - SHR treated with Tribulus terrestris (100mg/ Kg/ day). The drug was administered by gavage for 40 days. After this period, the penis was collected and processed for histomorphometric analysis. The following parameters were analyzed: penile cross-sectional area, densities of smooth muscle fibers, connective tissue and sinusoidal space. The results were compared by one-way ANOVA with Bonferroni post-test.

Results: There was no statistically significant difference in the cross sectional penile area. There was an increase in connective tissue density of 16.8% and 19.3% in the BPH and BPH+T groups when compared to the Ctrl group. There was a reduction of sinusoidal space of 34.7% and 22.4% in the BPH and BPH+T groups compared to the Ctrl group.

Conclusions: Rats with pre-disposition to arterial hypertension and BPH presented changes in the morphology of the corpus cavernosum. Treatment with Tribulus terrestris did not alter the morphology of the corpus cavernosum neither in control rats nor in hypertensive rats.

Financial support: This study received grants from CNPq, FAPERJ and CAPES.


Work supported by industry: no.

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