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Treating erectile dysfunction with a combination of low-intensity shock waves (LISW) and platelet-rich plasma (PRP) injections

Ruffo, A1; Stanojevic, N 2; Iacono, F3; Romis, L1; Romeo, G1; Di Lauro, G1

1: Hospital Santa Maria delle Grazie, Italy; 2: Sava Perovic Foundation, Serbia; 3: University of Naples Federico II, Italy

Objectives: In this study we investigated the effect of a combination therapy using low-intensity shosk-waves (LISW) and platelet rich plasma (PRP) injections to treat erectile dysfunction (ED).

Materials and Methods: 60 patients (pts) with mild to severe ED were enrolled in this study. Pts were randomly divided in Group A that underwent 6 weekly sessions of LISW (1500 shocks/session) and Group B that underwent 6 weekly sessions of LISW + 6 Injections of PRP (1 injection every 2 weeks). Pts were investigated at baseline and at 6 months after treatment using IIEF-5 and SEP-Q2 and SEP-Q3.

Results: At 6 months follow-up in Group A : IIEF-5 improved from 11 to 18, SEP-Q2 from 48% to 62%, SEP-Q3 from 28% to 48% while in Group B : IIEF-5 improved from 10 to 22, SEP-Q2 from 52% to 75%, SEP-Q3 from 30% to 62%. No Side effect were reported

Conclusions: LISW is now acknowledged as a first line treatment for the ED. The PRP is separated from other elements of the blood with the use of a centrifuge. The process involves the collection of the patient's whole blood before undergoing two stages of centrifugation that separates the PRP from other elements of the blood. PRP contains several different growth factors and other cytokines that can stimulate healing of soft tissue and tissue regeneration.In spite of the several studies previously reported, to date, a standardized protocol for PRP preparation and application, as well as a standard method for evaluating results has not been established. This preliminary data are quite encouraging. Further studies are needed in order to assess more precise protocols.


Work supported by industry: no.

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