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Is free testosterone good or evil for lower urinary tract symptoms? : analysis of a Japanese community-based study

Kobayashi, K1; Fukuta, F2; Takayanagi, A1; Hashimoto, K1; Tanaka, T1; Masumori, N1

1: Sapporo Medical University School of Medicine, Japan; 2: Sapporo Medical University School of Medicine, JapanSapporo Medical University School of Medicine, Japan

Objectives: Age-related testosterone deficiency may adversely affect the functions of multiple organ systems. Although it causes various clinical symptoms such as low libido, erectile dysfunction, depressed mood, decreased vitality and so on, the relationship between the low androgen level and lower urinary tract symptoms (LUTS) is not clear. We evaluated the relationship between androgen decline and LUTS based on data from a cross-sectional community-based study on LUTS suggestive of benign prostatic hyperplasia (BPH) in Japanese men.

Materials and Methods: In 2007, we conducted a cross-sectional community-based study on BPH/LUTS in aged men in Shimamaki-mura, Hokkaido, Japan. We investigated the International Prostate Symptom Score (IPSS) and measured the prostate volume and free testosterone level. A total of 91 of the 135 participants were eligible for this study. Associations between the free testosterone level and the IPSS and prostate volume were assessed by Spearman’s rank correlation.

Results: The median age of the participants was 69 years (range: 53-93). The median IPSS, prostate volume and free testosterone levels were 8 (range: 0-27), 24.5ml (range: 8.7-76.9) and 4.3pg/ml (0.6-9.0), respectively. Free testosterone was significantly and negatively correlated with the storage IPSS subscore (r=-0.239, p <0.05) and the frequency of nocturia (r=-0.280, p <0.05). A low level of free testosterone was also associated with large prostate volume (r=-0.210, p <0.05).

Conclusion: Our results show that a low free testosterone level causes the deterioration of storage symptoms and nocturia. The decline of this androgen may adversely affect BPH/LUTS in Japanese aged men.

Disclosure:

Work supported by industry: no.

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