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Cross-sectional association between testosterone and metabolic syndrome

Kim, M1; Ahn, TY1

1: Asan Medical Center, Korea, South

Objectives: Metabolic syndrome (MetS) which is a constellation of insulin resistance, hyperglycemia, hypertension, low high-density lipoprotein cholesterol (HDL), and increased low-density lipoprotein (LDL) and triglyceride (TG) levels. It is one of the main threats for public health in the 21st century with its associated risk of cardiovascular disease. Several studies have shown a higher prevalence of MetS in subjects with low testosterone. But the evidence of association is not sufficient for the Korean population. This study evaluated an association between testosterone and MetS in Korean population.

Methods: This observational study was performed using the regular health checkup cohort of Asan Medical Center consisting of 17,153 subjects. MetS was defined using the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATP III). The associations between MetS and testosterone were evaluated using linear mixed model and generalized estimating equation model.

Results: Of all subjects, the prevalence of MetS was 30.1%. After considering covariates such as age, body mass index (BMI), smoking, alcohol consumption and physical exercises, the risk of MetS defined by NCEP-ATP III criteria decreased by 31.0% with 1-standard deviation increase in total testosterone (TT). Metabolic component specific analysis showed that TT were inversely associated with several components of MetS including fasting blood sugar (FBS), waist circumference, serum HDL, TG, and blood pressure

Conclusions: Serum testosterone was inversely associated with MetS in Korean populations. But the evidence of association is not sufficient for the causation of MetS by low testosterone and long-term studies are needed to confirm whether T deficiency is the cause or is a feature of MetS.


Work supported by industry: no.

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