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Serum testosterone in diabetic men is not linked to diabetic control

Habous, M1Giona, S2; Binsaleh, S3; Abdelrahman, Z4; Nassar, M4; Tealab, A4; Mulhall, J5; Muir, G6

1: ELAJ MEDICAL CENTERS, Saudi Arabia; 2: king’s College Hospital,London,UK; 3: king Saud university,Riyadh,Saudi Arabia; 4: ELAJ MEDICAL CENTERS,SAUDI ARABIA; 5: Sexual and and reproductive medicine program, Memorial Sloan Kettering cancer center, NY USA; 6: King’s College Hospital,London,UK

 

Introduction: Diabetes Mellitus(DM) has been linked with low serum Testosterone(T) levels. Low testosterone levels in men with type 2 diabetes have been suggested to increase insulin resistance.

Objectives: We aimed to investigate if blood sugar control measured by glycosylated hemoglobin(HgA1c) correlates with T levels in diabetic patients.

Patients and Methods: A retrospective analysis of diabetic patients presenting to urology/andrology clinic for different complains (erectile dysfunction, decrease libido, infertility, lower urinary tract symptoms) all had T and HbA1c measured. Treated hypogonadism and hyper gonadotropic hypogonadism were excluded from the study.

Results:815 patients were included in this analysis with median age of 48 (20-83). Fifty patients hade type 1 DM while 765 had type 2 DM. The mean body mass index (BMI) was 30(16.7-54.4.) 368 patients (45%) were hypertensive. The mean T level was 4.2 ng/ml(0.9-13.8).The mean HgA1c was 8%(5-14), Interestingly a significant number of patients presented with undiagnosed diabetes ( 7 type 1,14%,and 83 type2,11%).T levels were not correlated with HgA1c, type of DM, duration of being diabetic or type of therapy(insulin, no therapy or oral).Also associated comorbidities were not correlated with T levels in either type of DM.

Conclusion: Testsoterone levels in diabetic men are not linked to blood sugar control.

Disclosure:

Work supported by industry: no.

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