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abstract

abstract

645

Nerves and vessels of the penis are altered by a diet with vitamin-D restriction in Wistar rats

Fernandes-Lima, F1; Gregorio, B1; Costa, W1; Nascimento, F1; Sampaio, F1Gallo, C1

1: State University of Rio de Janeiro, Brazil

Objective: Evaluate the effects of a diet restricted on vitamin-D in the vessels and nerves of the penis in Wistar rats.

Materials and methods: Female Wistar rats were divided into two groups: SC (standard diet) and VitD (vitamin-D restricted diet). The pups were divided according to the dams’ diet: SC/SC (fed a SC diet) and VitD/VitD (fed a VitD diet). Biometric and biochemical parameters were evaluated. After euthanasia, the penises were removed and processed for histomorphometric analysis. The areas of the lumen and middle tunica of the Dorsal Artery and the Deep Dorsal Vein were evaluated. The components of Dorsal Artery were quantified.

Results: Vitamin-D restricted diet induced metabolic changes as well as changes on penile morphology. The VitD/VitD group presented a reduction of the Deep Dorsal Vein area (p=0.0004) and of the Dorsal Artery lumen (p=0.004). There was hypertrophy of the tunica media of the Dorsal Artery in the VitD/VitD group (p=0.0156). The VitD diet reduced the percentage of vessels (p=0.047) and nerves (p<0.0001) in the dorsal region of the penis; decreased the elastic system fibers in the tunica media of the Dorsal Artery; and decreased the height of the internal elastic lamina of the Dorsal Artery (p<0.0001). The amount of elastic system fibers in the tunica media of the Dorsal Artery (p=0.0073) and the height of the internal elastic lamina of the Dorsal Artery (p<0.0001) were lower in the VitD / VitD group.

Conclusion: Vitamin-D restriction induced metabolic and structural changes in the vessels and nerves of the penis, which can impair the penile hemodynamic properties and cause erectile dysfunction in adults.

Disclosure:

Work supported by industry: no.

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