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abstract

abstract

414

The implication of aortic calcification on late onset hypogonadism in patients with end stage renal disease

Fujita, N1; Hatakeyama, S1; Yamamoto, H1; Imai, A1; Yoneyama, T1; Hashimoto, Y1; Koie, T1; Ohyama, C1

1: Hirosaki University Graduate School of Medicine, Japan

Background: Late onset hypogonadism (LOH) syndrome results in significant detriment in the Quality-of-Life (QOL). However, the prevalence of LOH syndrome in patients with end stage renal disease (ESRD) is unknown. Furthermore, relative-factors which influenced on severe aging male symptoms (AMS) remain unclear. Because vascular degradation is one of the predictors for aging, we hypothesized that preexisting aortic calcification may play a crucial role in severity of AMS. The aim of the present study was to investigate the implication of aortic calcification on AMS in patients with ESRD.

Methods: We treated 69 male patients with ESRD in our hospital. Of those, we included 42 patients with the age less than 75 years old. LOH syndrome was diagnosed when plasma free-testosterone concentration was less than 8.5pg/mL, based on Japanese LOH syndrome guideline. We evaluated patient background, including age, performance status, body mass index, dialysis vintage, diabetes mellitus, cardiovascular disease, antihypertensive medication, ankle brachial index, plasma testosterone concentration, plasma free-testosterone concentration, smoking history, current habitual drinking and aortic calcification index (ACI). Severity of AMS was investigated by Heinemann's AMS score. Multivariate regression analysis was performed to identify significant factors for influencing on AMS score.

Results: Median age was 63 years old. Of 42 patients, 19 (45%) were diagnosed as a LOH syndrome. In multivariate analysis, plasma free-testosterone concentration and ACI were selected as significant independent factors for severe AMS score in patients with ESRD.

Conclusions: Prevalence of LOH was 45% in patients with ESRD. Plasma free-testosterone concentration and ACI were independent factors for severe AMS score in patients with ESRD. Aortic degradation might be one of the surrogate markers for AMS and LOH syndrome in patients with ESRD.

Multivariate analysis

P-value

beta

95% CI

Plasma free-testosterone concentration

0.034

0.376

0.087-2.127

Aortic calcification index

0.048

0.318

0.001-0.248

 

Disclosure:

Work supported by industry: no.

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