Clinical trial with natural extracts from Lycium chinense for eugonadal men with late-onset hypogonadism-related symptoms: placebo-control, double-blind, randomized study
Bae, WJ1; Kang, SM1; Jeong, HC1; Choi, SW1; Kim, SJ1; Kim, SW1
1: Seoul St. Mary's Hospital, Korea, South
Objective(s); The purpose of this study was to evaluate the efficacy and safety of natural extracts from Lycium chinense on eugonadal men with late-onset hypogonadism(LOH)-related symptoms
Material and Method(s); Seventy-eight eugonadal men over 40 years of age with LOH-related symptoms were included in this study, and divided into two groups: treatment group and placebo-control group. Treatment was given orally to these patients three times daily for two months. Laboratory and endocrinological profiles were reviewed, and LOH symptoms were judged by means of several health assessment instruments such as the Aging Males’ Symptoms (AMS) scale.
Result(s); All patients represented no significant differences in vital sign, liver and kidney profile, urinalysis. In total score of AMS scale, placebo group had no significant change in mean score after treatment, but treatment group had decreased their score about 2.63 at 4 weeks and 2.69 at 8 weeks. (p=0.019, 0.038). In AMS subscale analysis, there were no significant differences in psychological and somatic subscale but significant decreased about 1.07 score at sexual subscale in treatment group. Lipid profiles were no definite changes between two groups and also in pre-treatment and post-treatment. PSA and serum testosterone level changes shows no significant difference between two groups.
Conclusion(s); We concluded that natural extracts from Lycium chinense may be considered for treatment of patients with LOH-related symptoms for eugonadal men.
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