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Correlation between PTEN expression and prostate cancer in Chinese population: a meta-analysis

An, Q1; Gu, YQ2

1: Graduate School of Peking Union Medical College, China; 2: National Health and Family Planning Key Laboratory of Male Reproductive Healthy,National Research Institute for Family Planning

Objective: To systematically review the correlation between PTEN expression and prostate cancer through clinic and pathologic features in Chinese population.

Methods: All the studies regarding the correlation between PTEN expression and prostate cancer in Chinese population were collected from the databases, including PubMed, Embase, CBM, CNKI, VIP and Wanfang as well. Meta-analysis was performed using Revman 5.3 software.

Results: A total of 26 studies were included, involving 1025 prostate cancer cases, 461 benign prostatic hyperplasia cases, and 37 controls. The results of meta-analysis showed that the prostate cancer group had a lower PTEN expression level when compared with the benign prostatic hyperplasia group [OR=0.03, 95%CI (0.02, 0.05), P<0. 01] and the control group [OR=0.03, 95%CI (0.01, 0.11), P<0. 01]. Moreover, the expression level of PTEN was lower in the low and medium differentiation group than in the high differentiation group [OR=0.20, 95%CI (0.15,0.27) ,P<0. 01], lower in the stage of C+D than in the stage of A+B [OR=0.11,95%CI (0.08,0.16) ,P<0. 01], and lower in the prostate cancer with metastasis [OR=0.10,95%CI (0.05,0.19),P<0. 01].

Conclusion: Current evidence indicates that the expression level of PTEN is significantly correlated with prostate cancer and its clinic pathologic features in Chinese population. Due to sample size and quality of included studies, the conclusion needs more large-scale, high quality and multi-center studies to be validated.

Disclosure:

Work supported by industry: no.

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