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A Meta-analysis and systematic review of dapoxetine for treatment of premature ejaculation

An, Q1; Gu, YQ2

1: Graduate School of Peking Union Medical College, China; 2: National Health and Family Planning Key Laboratory of Male Reproductive Healthy,National Research Institute for Family Planning

Objectives: To evaluate the efficacy and safety of Dapoxetine in treatment of premature ejaculation (PE) by meta-analysis.

Methods: PubMed, Embase, BIOSIS Previews Cochrane Library, CNKI Database and Wanfang Database was searcher for literatures on Dapoxetine in the treatment of PE, with key words of Intravaginal ejaculatory latency time (IELT), Patient reported global impression of change (PGI), Perceived control over ejaculation (PCOE) and Traditional chinese medicine (TCM)scores. Then meta-analysis was performed by using the Review Manager 5. 3, and the therapeutic efficacy and safety in relevant studies were summarized.

Results: 12 relevant trials were included which involving about 13,341 cases of PE. Compared with placebo controls, the patients treated with Dapoxetine showed significant improvement in IELT [WMD=1. 02, 95% CI (0. 65, 1. 39), P<0. 01], PGI [RR=1.76, 95% CI (1. 39, 2. 22), P<0. 01] and PCOE [RR=2. 09, 95% CI (1. 84, 2. 38), P<0. 01]. Meanwhile, there were significant differences between the 60mg and 30 mg Dapoxetine groups in IELT [WMD=0.40, 95% CI (0.25, 0. 55), P<0.01], PGI [RR=1. 17, 95 % CI (1. 09, 1. 25), P<0. 01) and PCOE [RR=1. 16, 95 % CI (1. 06, 1. 28), P<0. 01].

Conclusion: Both 60mg and 30mg Dapoxetine can significantly prolong IELT and greatly improve PGI and PCOE, with better effect for 60mg dose.


Work supported by industry: no.

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