Vacuum erection device and Phosphodiesterase5 inhibitors for the treatment of erectile dysfunction: a systematic review and meta analysis of randomized controlled trials
An, Q1; Gu, YQ2
1: Graduate School of Peking Union Medical College, China; 2: National Health and Family Planning Key Laboratory of Male Reproductive Healthy,National Research Institute for Family Planning
Objective: Systematic review and meta-analysis were conducted to find efficacy and tolerability of vacuum erection device (VED) combined with Phosphodiesterase-5 inhibitions (PDE5i) in the treatment of male erectile dysfunction (ED).
Methods: All the studies regarding the combination of vacuum erection device and PDE5i were collected from the databases, including PubMed, Embase, CBM, CNKI, VIP and Wanfang as well. Meta-analysis was performed by using Revman 5.3 software. Effect sizes were computed using Cohen’s D, and I2 test was used to assess heterogeneity.
Results: A total of 10 studies were included, involving 1327 cases. The results of meta-analysis showed that combination treatment group and VED group had significant differences when compared with PDE5i group [RR=1.34, 95%CI (1.17, 1.54), P<0. 01] and [RR=1.27, 95%CI (1.11, 1.46), P<0. 01]. Moreover, combination treatment group had great improvement in IIEF-5 scores [WMD= 4.52, 95%CI (2.54, 6.50), P<0. 01] while VED group [WMD=-2.07, 95%CI (-6.17, 2.03)] did not.
Conclusion: Current evidence indicates that the combination of PDE5i and VED are effective and safe for the treatment of sexual dysfunction in patients experiencing ED. Due to sample size and quality of included studies, the conclusion needs more large-scale, high quality and multi-center studies to be validated.
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