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How to pay attention on sexual dysfunction in Japanese patients with late-onset hypogonadism patients?

Amano, T1; Matsumoto, Y1; Kishikage, T1; Imao, T1

1: Nagano Red Cross Hospital, Japan

Objectives: Late-onset hypogonadism (LOH) syndrome is defined as several symptoms occur with decline of testosterone according to aging. Symptoms of LOH syndrome include physiological, psychological and sexual dysfunction. Many Japanese LOH patients mainly suffer from physiological and psychological problems, and have tendency to hesitate and/or ignore sexual dysfunction. However, we believe that sexual health is very important issues for LOH patients. The aim of this study is to evaluate and focus on erectile dysfunction (ED) in Japanese LOH patients retrospectively.

Material and Methods: Sexual health inventory for men (SHIM)for ED indicator were obtained from 576 LOH patients in our clinic. To investigate ED risk factors for Japanese LOH patients, the relationship between SHIM score and the other clinical data, including age, aging male symptoms (AMS) score, excess (powerful)–insufficiency (weakness) score (higher score indicates more powerful), international prostate symptoms score (IPSS), total and free testosterone levels were evaluated.

Results: Patients mean age was 54.1 +/- 10.7years-old, and mean SHIH score was 9.3 +/- 7.0. Univariate analysis (logistic regression analysis) of the relationship between SHIM score and the clinical data of LOH patients suggested that age, high AMS score, low excess –insufficiency score and low free testosterone level were considered to be ED risk factors. Furthermore, multivariate analysis with logistic regression analysis showed that age, high AMS score, and low excess-insufficiency score were considered to be significant risk factors for ED. However, there were no significant relationship between SHIM score and total testosterone level.

Conclusions: Sexual dysfunctions are not major complaints in Japanese LOH patients. However, LOH patients with high age, more insufficiency (weakness), and high AMS score might suffer from severe ED. On the other hand, serum total testosterone level was not useful as ED indicator for Japanese LOH patients. Thus, it is considered that there are several causes of ED in LOH patients besides testosterone deficiency.

Disclosure:

Work supported by industry: no.

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