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The organic erectile dysfunction associates premature arterial aging higher than the already expected because of the exposure to the traditional cardiovascular risk factors

Arroyo, C1Cedres, S1; Bia, D2; Zocalo, Y2

1: Uruguay; 2: CUIIDARTE, UDELAR, Uruguay

Introduction: The physiological aging process includes changes of arterial structure (carotid intima-media thickness, CIMT) and function (aortic stiffness). The exposure to cardiovascular risk factors (CVRF) causes detrimental changes and could accelerate age-associated changes determining "Accelerated vascular aging" (AVE). AVE, proposed as a clinical entity would have prognostic and therapeutic implications. It is unknown whether patients with organic erectile dysfunction (OED) have EVA and if so, if it is higher than expected by concomitant exposure to traditional cardiovascular risk factors.

Aims: To determine thepresence of AVE in men with OEDconsideringthe contribution ofexposure totraditionalcardiovascular risk factors.

Methods:22 menwithDEO(Group 1, 56±8 years),103 menwithout OED(Group 2, 58±8 years)withsimilarlyweightedexposure toCVRF(atherogenic index andoverall cardiovascularrisk) and36 menwere includedwithout exposuretoCVRF(Group3;agerange: 18-70years).Non-invasivebloodstudywas performed to determineCIMT(B-Mode Ultrasound) andaortic stiffness(pulse wave velocity, PWV, applanation tonometry). Age-associated changes were analized (linear regression). The comparison of groups1 and 3 informed the presence ofAVEin patients with OED (compared to physiologic aging). The comparison of groups1 and 2 let us evaluatethe presence of AVE associated with OED consideringthe contribution of othercardiovascular risk factors.

Results: The CIMT and PWV correlated linear and positively with age (p <0.05). In men with OED, higher IMT and PWV was observed (p <0.05). The increase rates (average value) for age-associated for the groups 1, 2 and 3 respectively were: 1) 0.012; 0.007; 0.005 mm / year for EIM and 2) 0.126; 0.091; 0.042 m / s / year for VOP (P <0.01).

Conclusion: The OED associates AVE and it is higher than the expected by concomitant exposure to cardiovascular risk factors. The AVE would contribute to increased cardiovascular vulnerability in men with OED.


Work supported by industry: no.

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