Status Plus




Erectile dysfunction associates own "arterial phenotype" defined by greater atherosclerotic burden, arterial stiffness and thickness and vascular reactivity lower than expected from exposure to risk factors

Cedres, S1; Arroyo, C 1; Zocalo, Y2; Bia, D2

1: Uruguay; 2: CUIIDARTE, UDELAR, Uruguay

Introduction: The organic erectile dysfunction (OED) is proposed as a cardiovascular risk factor (CVRF). However, patients with OED are exposed to multiple CVRF, not knowing if they have different arterial changes than the expected for the exposure to traditional CVRF. Furthermore, knowledge of the net level of arterial disease in patients with OED is limited.

Objective: To determine if men with OED have structural differences and / or arterial functional relation than men without OED: (a) with similar exposure to CVRF and (b) not exposed to CVRF.

Methods: We included 22 men with OED (Group 1, 56 ± 8 years), 103 men without OED (Group 2, 58 ± 8 years) with similarly exposure to CVRF (atherogenic index and overall cardiovascular risk) and 23 men with no exposure to CVRF (Group 3, 57 ± 10 years). In all of them clinical and medical history was analyzed with noninvasive blood study to determine 1) prevalence and burden of carotid and femoral atherosclerosis,2) Carotid intima-media thickness 3) pressure and aortic stiffness and 4): maximum humeral flow-mediated vasodilatation (FMV). The comparison of groups 1 and 2 allowed to determine own arterial characteristics of OED, not associated with traditional cardiovascular risk factors ("own arterial phenotype of OED"); Compare 1 vs. 3 evidenced the net alteration associated with OED.

Results: Men with OED had higher prevalence of carotid atherosclerosis, atherosclerotic burden, aortic stiffness and carotid thickness and FMV than than men in group 2 and 3 (Table). There was no difference in aortic pressure between groups. The prevalence of femoral atherosclerosis was similar between groups 1 and 2.

Conclusion: OED associates an own "vascular phenotype" defined by increased prevalence of carotid atherosclerosis and atherosclerotic burden, increased aortic stiffness and carotid thickness and less FMV respect of men without OED with similar exposure to CVRF. The OED associated greater arterial deterioration than the one explicable for the traditional CVRF.

Table (*: significant statistical difference compared to Group 1)

OED Men (Grupo 1)

Men with CVRF (Grupo 2)

Men without CVRF (Grupo 3)

Atherogenic index (total cholesterol / HDL)

3,96 (1,21)

4,52 (1,35)

3,83 (0,93)

CV disease risk score (Framingham,%; 10 years)

18,98 (6,39)

19,02 (8,70)

12,32 (7,79)*

Atherosclerosis Bulb / Common Carotid Left / Right (%)




More than 2 arterial segments with atherosclerosis (%)




More than 5 arterial segments with atherosclerosis (%)




Aortic stiffness (pulse wave speed; m / s)

9,88 (2,16)

9,03 (1,58)*

8,40 (1,14)*

Intima-media thickness left common carotid (mm)

0,91 (0,22)

0,80 (0,21)*

0,73 (0,10)*

Intima-media thickness right common carotid (mm)

0,84 (0,23)

0,76 (0,16)*

0,69 (0,07)*

Arterial flow-mediated dilatation (%)

3,31 (2,03)

4,89 (3,46)*

7,59 (6,70)*


Work supported by industry: no.

Go Back