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Prevalence of target organ damage in the arterial system of men with erectile dysfunction: diagnostic definition according to recommendations of the European Society of Cardiology and American Heart Association

Cedres, S1; Arroyo, C1; Zocalo, Y2; Bia, D2

1: Uruguay; 2: CUIDARTE, Universidad de la República, Uruguay

Introduction: The American Heart Association (AHA) and the European Society of Cardiology (ESC) recently defined diagnostic criteria to determine arterial target organ damage (TOD) associated with various entities. It is unknown: a) the prevalence of arterial damage in patients with organic erectile dysfunction (OED) and b) if the arterial damage is associated with OED and / or exposure to traditional cardiovascular risk factors (CVRF).

Objective: To determine the prevalence of arterial TOD in men with OED and evaluate its relationship with exposure to traditional CVRF.

Methods: Men with OED (Group 1, n = 22, 56 ± 8 years) and men without OED were included: a) with similarly exposure to CVRF (atherogenic index and overall cardiovascular risk) (Group 2, n = 103, 58 ± 8 years) and b) without exposure to cardiovascular risk factors (Group 3, n = 23, 57 ± 10 years). It was determined: 1) carotid intima-media thickness (IMT; B-Mode Ultrasound, image processing), 2) aortic stiffness (pulse wave velocity; tonometry), 3) Maximum brachial flow-mediated vasodilation (FMD). Following the recommendations of AHA and ESC, the DOB was defined as: CIMT> 0.9mm; VOP> 10 m / s; VMF <5%. We determined: prevalence of arterial abnormalities in men with OED, not explained by exposition to traditional CVRF (Group 1 vs. 2) and we analyzed the net prevalence of arterial DOB in men with OED, considering the one expected in healthy men of similar age without other CVRF (Group 1 vs. 3).

Results: Regardless of the group and indicator considered, the prevalence of DOB was higher in men with OED (Table).

Conclusion: The prevalence of blood DOB in men with DEO is higher than expected from exposure to traditional CVRF. The DEO associate higher blood vascular vulnerability and medical vascular evaluation could help to identify men with OED, with arterial damage and increased cardiovascular risk who would benefit from targeted prevention strategies.

Table 1 (* indicates significant difference from Group 1)

Group 1 (OED)

Group 2

Group 3

Age (years)

56,05 ± 8,11

58,66 ± 7,85

57,06 ± 10,35

Atherogenic index (total cholesterol / HDL)

3,96 ± 1,21

4,52 ± 1,35

3,83 ± 0,93

CV disease risk (Framingham,%; 10 years)

18,98 ±6,39

19,02 ± 8,70

12,32 ± 7,79*

 

 Prevalence (%)

Prevalence (%) 

 Δ% with Grupo 1

Prevalence (%)

Δ% with Grupo 1

Aortic stiffness (PWV)> 10 m / s

42,86

19,85*

-53,7

11,11*

-74,1

Left carotid IMT> 0.9 mm

38,89

22,90*

-41,1

5,56*

-85,7

Right carotid IMT> 0.9 mm

35,00

15,38*

-56,0

0,00*

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VMF < 5% (%)

80,95

55,77*

-31,1

58,33*

-27,9

Disclosure:

Work supported by industry: no.

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