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abstract

abstract

244

Analysis of microbiome prostatic secretion in depending of levels total testosterone in blood serum

Kogan, MI1; Ibishev, KS1; Cherny, AA1; Naboka, YL1Krakhotkin, DV1; Krainiy, PA1; Magomedov, RG1

1: Rostov State Medical University, Department of urology, Rostov-on-Don, Russia

 

Objective: Comparative analysis of microbiome prostate in depending of level testosterone (T) in blood serum Materials and methods: Analysis of diagnostics and results of treatment 124 patients with chronic bacterial prostatitis (CBP) who were divided on three groups: I group-patients with level T below 8 nmol/l , II group- level T 8-12 nmol/l (grey zone) and III group with normal level T ≥ 12,1 nmol/l.                        Results: In patients I group bacteriological study of prostatic secretion in all cases identified multicomponent aerobic-anaerobic associations with prevalence in the quantitative ratio non-clostridial anaerobes. Degree of contamination of facultative anaerobic bacteria in majority cases did not exceed 105 CFU/ml and non-clostridial anaerobes exceeded 106 CFU/ml. In II group patients like in I were determined aerobic-anaerobic associations with prevalence in the quantitative ratio non-clostridial anaerobes. In patients III groups in prostatic secretion predominated facultative-anaerobic microorganisms. Quantitative indicators of facultative-anaerobic microorganisms in majority cases matched 106 CFU/ml and non-clostridial anaerobic bacteria did not exceed 104 CFU/ml. During of conducted analysis by data of culture prostatic secretion was noted that the less level T in blood serum the more degree of associative relationships in prostatic secretion in patients with CBP. In I group specific weight four-component associations was insignificant (4,35%) most frequently determined five-component and six-component associations of microorganisms 19,5% and 26% respectively, seven-component associative relationships were identified in 17,4% cases and eight-component association bacteria in prostatic secretion in 32,6% patients. In II group more often observed three and four-component association bacteria 26% and 55,5%, respectively, rarely five-component association bacteria in 14,8% cases. The small specific weight constituted 6 associates which were found in prostatic secretion in patients with CBP and combined with testosterone deficiency-3.7%. In III group basically were identified two and three component association bacteria 37,2% and 39,2% and four and five component associative relationships microorganisms by 7,8% respectively.                                                                          Conclusions: Therefore in patients for bacteriological investigation prostatic secretion with level T below 12 nmol/l noted multicomponent associative bacterial relationships that can be exert the difficulties for administration antibacterial therapy.

Disclosure:

Work supported by industry: no.

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