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Peyronie’s Disease : predictive factors of good response to collagenase clostridium hystoliticum injections therapy

Capece, M1; Chiriacò, G1; Raheem, AM1; Ralph, DJ1

1: University College London Hospitals, UK

Objective: Recent advancements have been made for non-surgical treatment of Peyronie’s Disease (PD), with the most important being the intralesional injection of Collagenase Clostridium histolyticum(CCH). The aim of the study is to analyse the predicting factors of good response to this treatment.

Materials and Methods: A prospective study of 77 patients with PD who were going to receive three injections of CCH 4 weeks apart has been conducted. Patients have been taught to do modelling manoeuvres at home and to use vacuum pump every day. Erectile function, Peyronie’s disease and Global Assessment questionnaires have been administered to the patients. Duration of PD, age, presence of calcification, distance of the plaque from the corona, ED and waist deformities have been recorded and analysed as possible independent factors of good response to the treatment. The statistical analysis has been done with SPSS v.23.

Results: The mean (range) penile curvature at baseline was 55.6° (15°-90°). Of the 77 patients in the study, 74 patients (96.1%) had an improvement in the angel of curvature by a mean (range) of 18.5 (0-40)° or 33.1% (0%-73%) from baseline after three CCH injections. The final mean (range) curvature was 37.5 (12-75)° (P < 0.001). A logistic regression has been performed and the duration of PD is the only predicting factor that correlates with the result of correcting the initial curvature for more than 40% (p<0.05).

Conclusion: The safety and the effectiveness of CCH injections had already been confirmed in previous studies. In the present study we have analysed the possible predicting factors of good response to the treatment. In our model the longer the duration of PD is, the higher are the chances of improving the initial curvature for more than 40%.


Work supported by industry: no.

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