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Comparison of the effects and side effects between PDE-5 inhibitors combined with dapoxetine and single PDE-5 inhibitor for patients with premature ejaculation comorbid erectile dysfunction

Peng, J1; Zhang, ZC1

1: Peking University First Hospital, China

Objectives: Erectile dysfunction (ED) is common in patients with premature ejaculation (PE). Phosphodiesterase type 5 (PDE-5) inhibitors and dapoxetine can effectively treat ED and PE, respectively. However, PED-5 inhibitors can’t improve ejaculation control and dapoxetine can’t improve erectile dysfunction. It is controversial to how to treat PE comorbid ED. In this study, we aimed to compare the effect of combined sildenafil with dapoxetine and single sildenafil treatment and investigate the side effect of combination treatment.

Materials and methods: 42 patients with PE and secondary ED were treated in our center. 20 patients were administrated with sildenafil and dapoxetine, 22 patients with single sildenafil for 8 weeks. Data on premature ejaculation diagnostic tool (PEDT), self-reported intravaginal ejaculatory latency time (IELT), premature ejaculation profile (PEP), clinical global impression of change (CGIC) and International Index of Erectile Function-5 (IIEF-5) were recorded and compared between the combined treatment group and single treatment group before and after treatment.

Results: The mean age was 32.74±6.28 (range from 22 to 47) years. The mean duration of PE was 6.69±5.32 (range from 1 to 22) years. The baseline data between the 2 groups were not different. The self-reported IELT、PEDT、PEP and IIEF-5 score before treatment were not significantly different between 2 groups. After 8 weeks treatment, the self-reported IELT in combined treatment group was higher than that in single treatment group (P=0.003). Moreover, the IIEF-5 score in combined treatment was higher than single treatment group (P=0.041). The combined treatment could significantly improve the satisfaction with sexual intercourse (the question 5 in IIEF-5) (P<0.001). The proportion of patients reported CGIC≥1 in combined treatment group was higher than that in single treatment, but the difference was not statistically significant (80% vs 54.5%, P=0.265). The changes of IELT were significantly different between the 2 groups (105s vs 20s, P<0.001), however, the changes of IIEF-5 score had no difference (5.30±3.51 vs 3.77±2.25, P=0.098). The combined treatment did not increase the incidence of side effects.

Conclusion: The combination administration of sildenafil and dapoxetine could significantly improve IELT and IIEF-5 score than single treatment, but would not increase the side effect. Combined treatment might be recommended for patients with PE and ED.



Work supported by industry: no.

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