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Effectiveness of Dapoxetine combined with Tamsulosin in the treatment of premature ejaculation secondary to category IIIB chronic prostatitis: a multicenter clinical study

Tian, R1; Zhao, L1; Zhao, F1; Chen, H1; Liang, C1; Zhao, J1; Song, W1; Wang, Z1; Zhang, L1; Ji, Z1; Wei, B1Li, Z1; Xia, S1

1: China

Objective: The objective of this study is to assess the effectiveness of Dapoxetine combined with Tamsulosin in the treatment of acquired premature ejaculation (APE) in patients secondary to category IIIB chronic prostatitis (CP).

Materials and Methods: From February 2017 to September 2017, 187 patients, of which 157 patients were followed up at least for 4 weeks, who complained CP symptoms and then suffered from PE, presented to outpatient clinic in 11 hospitals. CP was defined according to physical examinations and National Institutes of Health Chronic Prostatitis Symptom Index scores (NIH-CPSI). APE was defined if intra-vaginal ejaculatory latency time (IELT) was less than 3 min according to International Society of Sexual Medicine (ISSM). The patients were randomly divided into Group 1 (Dapoxetine 30mg prn po, combined with Tamsulosin 0.2 mg qd po treatment, n = 107), and Group 2 (Tamsulosin 0.2 mg qd po treatment, n = 50). The patients were followed up in 4 weeks, 8 weeks, and 12 weeks. IELT and NIH-CPSI was recorded.

Results: During the follow-up, we found that both treatments could relieve the chronic prostatitis symptoms and prolonged IELT. In addition, we compared the effectiveness of both therapeutic regimen. The response rate of NIH-CPSI scores and IELT of both groups were presented in Table 1 and Table 2.

Table 1. NIH- CPSI scores in both groups before and after treatment.

Group 1

Group 2

P Value

Before treatment

23.37±7.40

25.20±9.10

0.2183

4 weeks after treatment

15.64±7.26 (n=107)

18.86±7.58 (n=50)

0.0138*

8 weeks after treatment

11.25±6.07 (n=84)

13.82±6.32(n=34)

0.0472*

12 weeks after treatment

7.75±4.78(n=63)

11.42±6.01(n=24)

0.0111*

Note: The data was presented as Mean ±SD.

Table 2. IELT scores in both groups before and after treatment.

Group 1

Group 2

P Value

Before treatment

1.13 (1,2)

1.5 (1,2)

0.6305

4 weeks after treatment

3 (2.1, 4.25) (n=107)

2 (1.38, 2.51) (n=50)

0.0001*

8 weeks after treatment

4 (3.5, 5.5) (n=84)

2 (1.6, 3.16) (n=34)

< 0.0001*

12 weeks after treatment

5.2 (4.05, 6) (n=63)

2 (1.32, 3.58) (n=24)

< 0.0001*

Note: The data was presented as M (p25, p75).

Conclusion: Dapoxetine combined with Tamsulosin relieved symptoms of both PE and CP. Treatment of Dapoxetine plus Tamsulosin was more effective than Tamsulosin alone in patients with APE secondary to category IIIB CP.

Disclosure:

Work supported by industry: no.

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