Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial
Abdelhamed, A1; Abu El-Hamd, M1
1: Sohag University, Egypt
Objectives: Premature ejaculation (PE) is the most prevalent sexual disorder in men. However, management of PE is still challenging. Therefore, the aim of the study was to compare the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with PE.
Material and Methods: In a single-blind placebo-controlled clinical study, 150 PE patients without erectile dysfunction (ED) were included during the period of March 2015 to May 2016. Patients were randomly divided into five groups (30 patients each). On demand placebo, paroxetine (30 mg), dapoxetine (30 mg), sildenafil citrate (50 mg) and combined dapoxetine (30 mg) with sildenafil citrate (50 mg) were given for patients for 6 weeks in each group respectively. All patients were instructed to record intravaginal ejaculatory latency time (IELT) and evaluated with Premature Ejaculation Diagnostic Tool (PEDT) and the patient satisfaction score before and after treatment.
Results: The age of the patients was 34.1 ± 5.85, and the duration of marriage was 6.85 ± 3.51 years. The duration of PE was 5.46 ± 2.7 years with the frequency of intercourse/week was 2.50 ± 0.7. Before treatment, the mean of IELT (s), the satisfaction score and PEDT was 38.9 ± 9.7, 0.95 ± 0.21, 17.12 ± 2.4 respectively. The mean of IELT, satisfaction score and PEDT in all groups was significantly improved after treatment (p value = 0.001). Combined dapoxetine with sildenafil group had the best values of IELT, satisfaction scores and PEDT in comparison with other treatment groups (p value <0.001).
Conclusions: This study concluded that the combined dapoxetine and sildenafil therapy for PE patients without ED could increase the patients IELT and satisfaction score with decrease of PEDT as compared to paroxetine alone or dapoxetine alone or sildenafil alone, with tolerated adverse effects.
Work supported by industry: no.Go Back