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Tadalafil 5mg on alternate days for treatment of erectile dysfunction

Moraes Veloso da Silveira, E1; Silva Peixoto de Carvalho, B1Borges Cabral Junior, J2; Falcao do Nascimento, E1; Dubourcq de Barros, F1; José Lisboa Lyra, R2; Cavalcanti Wanderley, G1; Amorim Moura Filho, S1; Lobo Fernandes Vieira, L1; Tenorio Lira Neto, F2

1: Hospital Getulio Vargas - Recife, Brazil; 2: ANDROSRECIFE, Brazil

Objective: Erectile Dysfunction (ED) is a problem prevalent all over the world. Tadalafil is a potent phosphodiesterase type 5 inhibitor (PDE 5) with a half-life (T1/2) of 17.5 hours and is an ideal option of a daily treatment. To assess the efficacy of Tadalafil 5mg used on alternate days for treatment of ED.      

Material and Methods: a prospective, interventionist and non-controlled study was carried out at the Hospital Getúlio Vargas’s Sexual Health Service, in the city of Recife, state of Pernambuco, Brazil, from May to October 2014. Men over 18 years of age, with a record of ED for a minimum of 3 months, were given Tadalafil 5mg on alternate days for 16 weeks. The International Index of Erectile Function (IIEF-5) was calculated at the first appointment and in subsequent visits every 4 weeks.

Results: A total of 120 patients (mean age of 56.9 years) completed the 16-week treatment. The majority (75%) had a record of ED of over 12 months. The IIEF-5 average showed a significant increase from 10.60 in the initial assessment to 22.90 in the final assessment (p < 0,001). Upon the initial assessment, most patients were rated as moderate ED (35%) or severe (25%). After the 16-week treatment, only 5% of patients fell in these two categories while 75% of the sample showed an absence of ED.

Conclusion: Tadalafil 5mg on alternate days led to a significant improvement in erectile function with an increase of 12.3 points in IIEF-5 following a 16-week treatment. Furthermore, 75% of the patients reached normal erectile function.


Work supported by industry: no.

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